How can polynucleotide treatment benefit my under-eye area?

Polynucleotide treatment can help by: - Making dark circles look less noticeable - Smoothing out crow's feet and fine lines under the eyes - Improving skin hydration and circulation in this sensitive area Polynucleotides help increase collagen and elastin by activating fibroblast cells, as well as promoting tissue regeneration and restoring skin tone and elasticity. They also have antioxidant and hydrating properties, which can make the skin look and feel healthier.

When will I see the results?

Patients can expect to see improvements after 2-4 treatments, between 3-4 weeks apart, which can last 6-9 months.

What happens during the polynucleotide treatment?

First, we will take a photo of you before the treatment. Then, we will apply a numbing cream on your eyelids and wait for 10-20 minutes for it to work. The actual treatment usually takes less than 15 minutes. You may see some immediate results, but there could be some swelling and bruising afterwards. If you have dark circles under your eyes along with a sunken area, you may need special skincare to help with the dark circles too.

Are polynucleotide fillers painful?

We use a numbing cream under the eyes before the treatment, so the injections should not be painful.

What are the side effects and recovery time?

You might have some mild swelling and bruising, but it shouldn't last long and can be covered with makeup. Our goal is to give you a natural look, and any swelling or bruising should go away fairly quickly.

Who should avoid this treatment?

This treatment is not suitable for vegetarians, vegans, or individuals with fish allergies because it contains animal products. It is also not recommended for use during pregnancy or while breastfeeding.

Can I consume alcohol before getting this treatment?

We advise against consuming alcohol at least 24 hours before the treatment as injections can lead to bruising.

Experts in Under Eye Polynucleotides in London

Polynucleotide treatment is a medically indicated procedure aimed at supporting the skin’s natural regenerative processes in the under-eye region. It is used in cases where there is a medical need, such as post-traumatic changes, post-surgical irregularities, or tissue repair, rather than purely cosmetic enhancement.

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Before & After Polynucleotides before and after, a patient of Dr Sabrina Shah-Desai

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Polynucleotides

At a Glance

Duration: 15 Minutes
Driving: Immediately
Anaesthesia: Topical
Hospital Stay: Day Case
Exercise: 24 Hours
Final results: 6-9 Months

Why choose this treatment

Advantages of Polynucleotide Treatment

Hydration

Polynucleotides boost moisture and circulation under the eyes, leaving skin looking smoother and more radiant.

Cellular Regeneration

Polynucleotides stimulate cell renewal, restoring a youthful glow and freshness to the eye area.

Skin Density and Strength

Polynucleotides increase collagen production, firming the skin and reducing fine lines and wrinkles.

Dark Circles

Polynucleotides repair damaged blood vessels, reducing the appearance of dark circles and discolouration.

The Treatment

What are Polynucleotides?

Polynucleotides are fragments of Fish DNA in a saline injectable gel that aim to help repair tissue by stimulating fibroblasts, encouraging cell turnover, improving elasticity, and boosting collagen production and hydration of the skin.

Those who are susceptible to swelling after conventional dermal fillers or are concerned about complications associated with dermal fillers, and have very thin under-eye skin are ideal candidates. Polynucleotides enhance the skin's quality by encouraging the body's natural regenerative processes.

Under-Eye Regeneration What are Polynucleotides?

Polynucleotide Injection How Does the Polynucleotide Procedure Work?

The Procedure

How Does the Polynucleotide Procedure Work?

1. Preparation: Topical numbing cream is applied for 15 minutes.

2. Injection: Using a fine needle or cannula, Polynucleotides are carefully administered into the under-eye tissue.

3. Mechanism: Polynucleotides signal cells to stimulate collagen, hyaluronic acid, and tissue regeneration, supporting gradual improvement in skin quality.

Key Notes: Results are gradual and subtle, suitable for natural improvements rather than dramatic aesthetic changes. Minimal downtime; mild swelling or bruising is possible for a few days. The procedure must be performed by a qualified medical professional.

Real Patient Results

Polynucleotides Before and After

See the Polynucleotides before and after results below, achieved by Dr Sabrina.

Polynucleotides before and after - case 2

Polynucleotides before and after - case 3

Disclaimer: Your results may vary. Any specific claims or duration of results vary for each patient and are not guaranteed.

Meet the Expert: Dr Sabrina Shah-Desai

Dr Sabrina Shah-Desai is the founder and Medical Director of Perfect Eyes Clinic. With over two decades of surgical and non-surgical experience, she is considered one of the safest, most experienced oculoplastic surgeons in the UK.

Her extensive training, combined with her caring and empathetic nature, makes her a natural choice for patients seeking the very best care. Dr Sabrina appears consistently in Tatlermagazine as one of the UK's “Best Eye Surgeons” and “Top Doctors” since 2019.

Learn About Dr Sabrina

Royal College of Surgeons of England - register of Board-Certified Cosmetic SurgeonsBest Aesthetic Doctor - Safety in Beauty 2023Consultant Surgeon of the YearBest Surgical Result - Aesthetic Awards 2021Tatler Best Eye Surgeon 2019-2026

Transparent pricing

Polynucleotides Cost in London

Prices are a guide; your surgeon confirms the total during consultation.

Polynucleotide (Eyes or Face) Cost £480 Per Treatment

Important: all cosmetic procedures incur 20% VAT. Fees are estimates and will be confirmed after medical consultation.

Book a medical consultation

Patient Questions About Polynucleotides

Frequently Asked Questions

The questions patients ask most often, answered by the clinic. If yours isn’t here, ask us directly - we would be delighted to help.

Polynucleotide treatment can help by:

- Making dark circles look less noticeable
- Smoothing out crow's feet and fine lines under the eyes
- Improving skin hydration and circulation in this sensitive area

Polynucleotides help increase collagen and elastin by activating fibroblast cells, as well as promoting tissue regeneration and restoring skin tone and elasticity. They also have antioxidant and hydrating properties, which can make the skin look and feel healthier.
Patients can expect to see improvements after 2-4 treatments, between 3-4 weeks apart, which can last 6-9 months.
First, we will take a photo of you before the treatment. Then, we will apply a numbing cream on your eyelids and wait for 10-20 minutes for it to work. The actual treatment usually takes less than 15 minutes. You may see some immediate results, but there could be some swelling and bruising afterwards. If you have dark circles under your eyes along with a sunken area, you may need special skincare to help with the dark circles too.
We use a numbing cream under the eyes before the treatment, so the injections should not be painful.
You might have some mild swelling and bruising, but it shouldn't last long and can be covered with makeup. Our goal is to give you a natural look, and any swelling or bruising should go away fairly quickly.
This treatment is not suitable for vegetarians, vegans, or individuals with fish allergies because it contains animal products. It is also not recommended for use during pregnancy or while breastfeeding.
We advise against consuming alcohol at least 24 hours before the treatment as injections can lead to bruising.

Call or email us today, we would be delighted to answer your questions.

Ask a Question or Book an Appointment

Patient stories

Rated five stars by patients across the globe

4.8out of 5 from 240+ Google reviews

Desi Stevens

“Simply the best dermatologist for skin care and eye surgery. She is a safe and skilled doctor who is highly experienced and will meet your needs, her approach is a soft and natural aesthetic. She listens and communicates clearly, professionally and in a kind and personable manner. I have been looked after by Dr Sabrina for many years have always been extremely happy with her advice, procedures and results. Highly recommend, she is a talented Dr you can trust.”

Kealey Hessey

“Dr Sabrina is the magic eye fairy. Only 10 days after my lower lid bleph and midface lift and nearly all bruising and swelling has gone. After a lot of research, I knew after my initial consultation with Dr Sabrina she was the one I trusted. Such a warm & kind woman. I am so pleased I put my Trust in Dr Shah. Immensely happy with the results and will be back to get my upper eyes done in the future. Thank you to the whole team.”

Jo Kirby

“I had been recommended Dr Sabrina by a medical colleague & am extremely glad I made the journey from Southampton to the Perfect Eye Clinic in London to discuss blepharoplasty. The team were all so friendly & very professional and most importantly, Dr Sabrina informed me that I had a bilateral eye ptosis. This explained a number of issues I was experiencing. I will definitely be booking to have a correction of bilateral eye ptosis and upper blepharoplasty. Can't recommend enough.”

Shirley Ford

“I am so very happy with my experiences at Perfect Eyes. Dr Sabrina is an absolute Star. Extremely talented, very personable I just couldn't be happier with my results and her overall professionalism. But a big part of my review is how lovely the support staff are too. Namely Safiya and Lisa who greet you with such warmness and respect. I highly recommend this clinic as I have done so with many friends.”

Radhika Rajan

“Top notch surgeon. Dr.Sabrina Shah is the best. Very meticulous and focused. Very experienced and very skillful. Supported by a great team, Irvana at the office is efficient and directs empathy as well towards nervous patients like myself . All in all a great experience.”

Tina Stonely

“Dr Sabrina is so so kind and thorough in really assessing and understanding my needs and explaining in detail what works and the pros on cons of each treatment. I trust her implicitly and know she is the best physician in the UK and trainer to physicians for all aesthetic treatments. I cannot recommend her enough. You will not be disappointed choosing Sabrina.”

Tanya Del Federico

“Perfect Eyes provides an exceptional experience from start to finish. The team is warm, professional and highly knowledgeable, and every aspect of the consultation feels thorough and personalised. Sabrina combines outstanding surgical expertise with a genuine commitment to achieving natural, elegant results, taking the time to explain every option and ensure patients feel completely at ease. The care, attention to detail and standard of service are second to none. I would highly recommend Perfect Eyes to anyone looking for expert oculoplastic and aesthetic care.”

Minda Wang

“I am so happy with my experience. The results look natural, and I feel like a fresher version of myself since having my Biostimulation treatment with Doctor Sabrina. The whole experience was comfortable and professional, and I felt supported and well cared for throughout. I would definitely recommend this treatment to anyone looking for a natural-looking boost.”

Samantha Andrews

“Amazing. I’m so happy with the results. Sabrina is a master. She also has a wonderful bedside manner. I can’t recommend Sabrina and her team enough. Worth double the money. 👏🏻”

Hayley Pearson

“I was lucky enough to first meet Sabrina 9 years ago & have never used anyone else since. She has helped transform my appearance; with natural looking aesthetics. I currently live abroad, however remain dedicated to stay a patient of Sabrina. What’s 3,500 miles when you have found the best in the business!”