Is the treatment painful?

Most clients find the procedure comfortable, as it’s performed with ultra-fine needles. A numbing cream can be applied to reduce any discomfort.

Can you feel polynucleotides working?

You won’t feel them working right away, as the treatment works deep within the skin at a cellular level. However, within a few weeks, you may start to notice your skin feeling more hydrated and looking smoother. Most people see the biggest improvements by around 12 weeks.

How long does a session take?

Most treatments take around 30 to 45 minutes.

Is there any downtime?

You may have some mild swelling or redness for 24 to 48 hours, but most people can return to normal activities the same day.

How many treatments will I need?

Usually 3 to 4 sessions are recommended, spaced 2 to 3 weeks apart.

Can I combine it with other treatments?

Yes. Polynucleotides work well alongside treatments like microneedling, skin boosters, or LED therapy, depending on your goals.

Do Polynucleotides Really Work?

If you’ve been keeping an eye on new skin treatments, you’ve probably heard the word polynucleotides. They’re rapidly becoming popular in regenerative aesthetic treatments. These powerful molecules were first utilised in medical treatments, such as wound healing, but are now being applied to enhance skin health & appearance. They don’t just sit on the surface. These molecules actually work deep within the skin, encouraging your cells to repair, hydrate and rebuild themselves over time. But with so many skincare trends coming and going, it’s natural to ask, do polynucleotides really work, or is it just another hype? Let’s break it down.

What Are Polynucleotides?

Polynucleotides are natural molecules composed of nucleotide chains. They’re most commonly sourced from salmon DNA due to its strong compatibility with human skin and tissue. These molecules are purified and processed. They are generally used in injectable treatments to stimulate the natural regeneration processes of your skin. They are biocompatible, biodegradable, and designed to repair & regenerate tissue at a cellular level.

Do Polynucleotides Work?

Yes, polynucleotides are known to be effective in improving skin quality, but the results take a bit of time to show. They work by supporting your skin’s natural repair process, helping it produce more collagen & elastin while boosting hydration. Some people start to see changes after a few weeks, but the full results usually appear over a few months with consistent treatment.

Polynucleotides Results

How Do Polynucleotides Work?

Polynucleotides work deep within the skin to repair, restore, and improve the overall quality of your skin. They don’t add volume like fillers. Instead, they act as biostimulators, which encourage your skin to heal and rebuild itself from the inside. When injected just under the surface using a fine needle, polynucleotides trigger fibroblasts (the skin cells responsible for producing collagen and elastin). It helps tighten the skin, reduce fine lines, and gradually boost elasticity. They also boost hydration by attracting water molecules, improving skin texture, calming inflammation & supporting tissue repair in damaged or ageing areas. A major benefit is their ability to neutralise free radicals, which helps slow down visible signs of age. You can apply this treatment to specific areas, like under the eyes. This works beautifully on delicate areas that require a gentle touch while still delivering noticeable rejuvenation.

Are Polynucleotides Safe?

Yes, polynucleotide treatments are generally very safe. In skin treatments, polynucleotides are usually taken from natural sources like fish, but they go through a careful purification process to make them safe and suitable for the human body. Polynucleotide treatment is generally considered safe when performed by a trained and skilled medical practitioner. Like with any injectable treatment, there can be some mild side effects, such as bruising or swelling. Since polynucleotides are made from substances already found in our body, most people tolerate them well and allergic reactions are very rare. Still, it’s important to have your treatment done at a trusted clinic with the right expertise, so any risks can be handled safely and quickly if needed.

When Can You Expect Polynucleotides Results?

Polynucleotide treatments work gradually, as they help your skin heal and rebuild itself from the inside. You may see early signs of improvement within a couple of weeks, but full results take a bit more time as collagen and elastin levels increase.

Here’s what to expect:

1 to 2 weeks: You might notice your skin feels more hydrated and looks slightly brighter. These are the first signs that the treatment is starting to work.
4 to 6 weeks: More visible changes like smoother skin, better elasticity, and softer fine lines start to show as your skin produces more collagen.
8 to 12 weeks: This is when you’ll likely see the best results. A complete treatment generally involves 2 to 3 sessions that are scheduled every 2 to 4 weeks.
6 to 12 months: Results can last several months. To maintain your skin’s improved look, top-up treatments may be required once or twice a year.

Everyone has a different skin type, so the timing of results can vary based on age, skin condition, and overall health.

Who Can Benefit from Polynucleotides?

This treatment is suitable for people who:

Are experiencing early signs of ageing.
Have sensitive or acne-prone skin.
Want to improve under-eye hollowness or dark circles.
Are looking for a regenerative boost without drastic changes.

It’s also ideal for individuals who prefer non-invasive or low-downtime treatments that support the skin’s natural functions.

Final Thoughts

Polynucleotides are a great option for people looking to improve their skin in a gentle and natural way. Instead of quick fixes, polynucleotides treatment focuses on long term skin health by repairing your body and rebuilding it from within. They are safe & effective and offer visible improvements in skin quality without changing your natural appearance. If you’re looking for a treatment that supports your skin’s natural beauty, polynucleotides are definitely worth considering.