When will I see results?

Following a course of 2-3 treatments every 3-4 weeks, you can expect to see results.

What is the downtime?

There is minimal downtime, however you might experience some bruising, redness or swelling in the treated area. If this happens, it usually subsides within a matter of days, and can be easily covered by makeup.

Is treatment painful?

No, as a numbing cream is usually applied beforehand.

How long does the treatment result last?

This is a newer treatment in regenerative aesthetics and currently we believe the treatment needs to be repeated annually.

What are the risks of Polynucleotides/Mesotherapy?

Following treatment an incomplete improvement may occur. If this happens, further treatments like under-eye hyaluronic acid filler or energy-based treatments may be required.

Dark Circles and Polynucleotides or Mesotherapy

Polynucleotides and mesotherapy stimulate collagen production and cell turnover to brighten and rejuvenate the delicate under-eye area.

Take the Free Self-Test Book Consultation

Dark Circles and Polynucleotides or Mesotherapy illustration

Accredited & recognised by

At a Glance

Duration: 15 Minutes
Anaesthesia: Numbing Cream
Down time: Minimal
Course: 2-3 Sessions, Every 3-4 Weeks
Final results: Repeated Annually

Why choose this treatment

Advantages of Dark Circles and Polynucleotides or Mesotherapy Treatment

Gradual Results

Perfect for those seeking a natural, subtle improvement.

Negligible Downtime

You may be a little bruised for a few days.

Unrivalled Expertise

Performed by a leading oculoplastic surgeon and her team.

What are Polynucleotides or Mesotherapy?

Whilst hyaluronic acid fillers are a standard method of treating the under-eye hollows, Polynucleotides are shortened DNA fractions, whilst mesotherapy are injections that contain numerous nutrients and enzymes. Both encourage regenerative changes on a cellular level and are a newer alternative to treating loose, wrinkly skin and dark circles. The benefits include increased cell turnover, improved skin elasticity, reduced skin hyperpigmentation, reduced infraorbital hollows due to thin skin, improved fine lines, and boosted hyaluronic acid production to give a brighter under-eye area.

How Does the Procedure Work?

Dr Sabrina will often use a numbing cream which is applied for 15 minutes prior to the procedure. The whole procedure takes around 15 minutes, and a fine needle is used to perform the treatment. Polynucleotides (PDRNs) work by signalling to particular cells in the body to change their behaviour and generate collagen, hyaluronic acid and fat. These result in a tighter, brighter, more lifted appearance naturally, but it takes time and a course of treatments.

Meet the Expert: Dr Sabrina Shah-Desai

Dr Sabrina Shah-Desai is the founder and Medical Director of Perfect Eyes Clinic. With over two decades of surgical and non-surgical experience, she is considered one of the safest, most experienced oculoplastic surgeons in the UK.

Her extensive training, combined with her caring and empathetic nature, makes her a natural choice for patients seeking the very best care. Dr Sabrina appears consistently in Tatlermagazine as one of the UK's “Best Eye Surgeons” and “Top Doctors” since 2019.

Learn About Dr Sabrina

Royal College of Surgeons of England - register of Board-Certified Cosmetic SurgeonsBest Aesthetic Doctor - Safety in Beauty 2023Consultant Surgeon of the YearBest Surgical Result - Aesthetic Awards 2021Tatler Best Eye Surgeon 2019-2026

Patient Questions About Dark Circles and Polynucleotides or Mesotherapy

Frequently Asked Questions

The questions patients ask most often, answered by the clinic. If yours isn’t here, ask us directly - we would be delighted to help.

Following a course of 2-3 treatments every 3-4 weeks, you can expect to see results.
There is minimal downtime, however you might experience some bruising, redness or swelling in the treated area. If this happens, it usually subsides within a matter of days, and can be easily covered by makeup.
No, as a numbing cream is usually applied beforehand.
This is a newer treatment in regenerative aesthetics and currently we believe the treatment needs to be repeated annually.
Following treatment an incomplete improvement may occur. If this happens, further treatments like under-eye hyaluronic acid filler or energy-based treatments may be required.

Call or email us today, we would be delighted to answer your questions.

Ask a Question or Book an Appointment

Patient stories

Rated five stars by patients across the globe

4.8out of 5 from 240+ Google reviews

Desi Stevens

“Simply the best dermatologist for skin care and eye surgery. She is a safe and skilled doctor who is highly experienced and will meet your needs, her approach is a soft and natural aesthetic. She listens and communicates clearly, professionally and in a kind and personable manner. I have been looked after by Dr Sabrina for many years have always been extremely happy with her advice, procedures and results. Highly recommend, she is a talented Dr you can trust.”

Kealey Hessey

“Dr Sabrina is the magic eye fairy. Only 10 days after my lower lid bleph and midface lift and nearly all bruising and swelling has gone. After a lot of research, I knew after my initial consultation with Dr Sabrina she was the one I trusted. Such a warm & kind woman. I am so pleased I put my Trust in Dr Shah. Immensely happy with the results and will be back to get my upper eyes done in the future. Thank you to the whole team.”

Jo Kirby

“I had been recommended Dr Sabrina by a medical colleague & am extremely glad I made the journey from Southampton to the Perfect Eye Clinic in London to discuss blepharoplasty. The team were all so friendly & very professional and most importantly, Dr Sabrina informed me that I had a bilateral eye ptosis. This explained a number of issues I was experiencing. I will definitely be booking to have a correction of bilateral eye ptosis and upper blepharoplasty. Can't recommend enough.”

Shirley Ford

“I am so very happy with my experiences at Perfect Eyes. Dr Sabrina is an absolute Star. Extremely talented, very personable I just couldn't be happier with my results and her overall professionalism. But a big part of my review is how lovely the support staff are too. Namely Safiya and Lisa who greet you with such warmness and respect. I highly recommend this clinic as I have done so with many friends.”

Radhika Rajan

“Top notch surgeon. Dr.Sabrina Shah is the best. Very meticulous and focused. Very experienced and very skillful. Supported by a great team, Irvana at the office is efficient and directs empathy as well towards nervous patients like myself . All in all a great experience.”

Tina Stonely

“Dr Sabrina is so so kind and thorough in really assessing and understanding my needs and explaining in detail what works and the pros on cons of each treatment. I trust her implicitly and know she is the best physician in the UK and trainer to physicians for all aesthetic treatments. I cannot recommend her enough. You will not be disappointed choosing Sabrina.”

Tanya Del Federico

“Perfect Eyes provides an exceptional experience from start to finish. The team is warm, professional and highly knowledgeable, and every aspect of the consultation feels thorough and personalised. Sabrina combines outstanding surgical expertise with a genuine commitment to achieving natural, elegant results, taking the time to explain every option and ensure patients feel completely at ease. The care, attention to detail and standard of service are second to none. I would highly recommend Perfect Eyes to anyone looking for expert oculoplastic and aesthetic care.”

Minda Wang

“I am so happy with my experience. The results look natural, and I feel like a fresher version of myself since having my Biostimulation treatment with Doctor Sabrina. The whole experience was comfortable and professional, and I felt supported and well cared for throughout. I would definitely recommend this treatment to anyone looking for a natural-looking boost.”

Samantha Andrews

“Amazing. I’m so happy with the results. Sabrina is a master. She also has a wonderful bedside manner. I can’t recommend Sabrina and her team enough. Worth double the money. 👏🏻”

Hayley Pearson

“I was lucky enough to first meet Sabrina 9 years ago & have never used anyone else since. She has helped transform my appearance; with natural looking aesthetics. I currently live abroad, however remain dedicated to stay a patient of Sabrina. What’s 3,500 miles when you have found the best in the business!”