Autologous Exosomes
Skin & Hair Rejuvenation

We are the first & only clinic in UK to be offering AUTOLOGOUS (your own) platelet derived exosomes, using a unique combination system of centrifugation and ultrafiltration to harvest high quality exosomes.

What are Exosomes?

Exosomes are the latest buzz word in the field of regenerative medicine and skincare, offering an innovative potential in skin rejuvenation. Exosomes are small vesicles secreted by various cell types, including stem cells. They contain bioactive molecules such as growth factors, cytokines, and microRNAs, which can influence cellular communication and regeneration. When used in skincare, exosomes are often derived from stem cells and can have several potential benefits for skin rejuvenation that include:

  1. Anti-Aging Properties: Exosomes are believed to contain growth factors and signaling molecules that may stimulate collagen production and elastin formation. This can help improve skin elasticity and reduce the appearance of fine lines and wrinkles.
  2. Skin Repair: Exosomes may promote tissue repair by enhancing the skin’s ability to regenerate and heal. This can be particularly beneficial for individuals with damaged or scarred skin.
  3. Skin Hydration: Exosomes can help improve skin hydration by promoting the production of hyaluronic acid, a natural moisturizing factor that retains water in the skin.
  4. Reduction of Inflammation: Exosomes have anti-inflammatory properties and may help reduce skin inflammation and redness, making them suitable for individuals with conditions like rosacea or sensitive skin.
  5. Pigmentation: Exosomes may help even out skin tone and reduce hyperpigmentation by influencing melanin production and distribution.
  6. Enhanced Penetration: Exosomes can serve as carriers for other active ingredients, helping them penetrate the skin more effectively. This can enhance the overall efficacy of skincare products.
  7. Minimal Risk of Allergic Reactions: Exosomes are typically well-tolerated by the skin, making them a suitable option for individuals with sensitive skin or those who have experienced allergies with other skincare ingredients.

They can also be used in promoting hair growth and improving hair quality, by stimulating hair follicle stem cells to promote hair growth and thickening. A study from 2021 (Yang GH, Lee YB, Kang D, Choi E, Nam Y, Lee KH, You HJ, Kang HJ, An SH, Jeon H. Overcome the barriers of the skin: exosome therapy. Biomater Res. 2021 Jul 3;25(1):22), showed that exosomes stimulate collagen synthesis, reduce inflammation, and promote angiogenesis (the formation of new blood vessels). A large number of scientific aesthetic practitioners are of the opinion that it is this combination of three different characteristics can be utilised for

  • Skin regeneration and treating dermatological conditions like acne, eczema and psoriasis
  • Hair loss reduction
  • Wound/scar repair

What are Autologous Exosomes?

Autologous exosomes are exosomes derived from an individual’s own body, making them “self-derived” or “self-sourced.” These exosomes are obtained from the person’s tissues/cells and then used for various therapeutic or regenerative purposes. The term “autologous” signifies that there is no risk of immune rejection or adverse reactions, as the exosomes are derived from the same person who will receive the treatment.

What is the treatment procedure with Autologous Exosomes?

Here are some key points to understand about autologous exosomes and how we harvest them. Plan to be in the clinic for 60-90 mins. Note you can be a bit bruised and swollen for between 1-7 days after the treatment, so factor that into planning the treatment.

  1. Source: Autologous exosomes are typically isolated from a patient’s own blood cells. We take 60 ml of your blood, it is a relatively painless procedure (similar to blood being taken from a vein for a blood test). We request you eat food 1-2 hours prior to having the treatment and are well hydrated with water. Avoid alcohol 24 hours prior to the treatment.
  2. Production Process: To obtain autologous exosomes, the patient’s cells are centrifuged and then concentrated and purified using ultrafiltration for immediate therapeutic use. We get a final 5- 6 ml of the exosome cocktail for injection into the skin of the face and neck or the scalp from 60 ml of blood collected.
  3. Treatment Procedure: The skin of the face and neck or the scalp is numbed for 20-30 mins (this is done whilst the exosomes are being prepared). The skin is cleansed. Multiple fine painless injections are performed using an invisible needle to inject the exosomes into the dermis of the skin or into the scalp.

If the treatment is being performed after micro-needling or LASER, then the exosomes are just applied into the treated skin.

NOTE: We prepare and inject autologous exosomes immediately, thus ensuring high viability.

Summary

Literature review over 10 years showed promise in animal and cell models and in early clinical trials for skin rejuvenation, scar revision, hair restoration, and fat graft survival. Exosomes show promise in several areas of nonsurgical rejuvenation; however, further studies are warranted to determine whether this modality is superior to PRP and fat grafting.

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Patient Questions

Commonly Asked Questions about Autologous Exosomes Skin & Hair Rejuvenation

What are the differences between all the variety of exosome products available?

There are a lot of exosome brands on the market. The primary differences between these manufacturers’ exosomes are the concentration (or number) of exosomes in the end product and the source of the exosomes themselves.

The current common sources of exosomes used in most other aesthetic medical treatments are generally NON-AUTOLOGOUS – which means they are taken from a HUMAN DONOR – these include placental stem cells, adipocytes and platelets. As using exosomes from ohuman donors is banned in UK (and many other countries) Plant derived and Salmon derived exosomes are also available

Effective Exosomes are from live cells. However, Exosomes either require storage in a special deep freezer and need to be defrosted before use or need to be kept refrigerated and then reconstituted before use.

Anything with true exosomes will not be very shelf stable and will have a short lifespan. Kimera (Miramar, Fla.), Regan Suppliers (Scottsdale, Ariz.), and Exocel Bio (San Diego, Calif.) provide aqueous exosome solutions that require frozen storage with a shelf life between 6 months to a year. Once thawed, the products can either be applied directly over the skin or mixed with saline. The unused thawed solution can be stored in a refrigerator for up to 48 hours. In contrast, Benev (Mission Viejo, Calif.) provides a freeze-dry “lyophilized” form, which requires reconstitution before use. The freeze-dry form can be stored at room temperature for up to 2 weeks before reconstitution; however, the reconstituted material must be used within 20 minutes of activation.

Plant-derived exosomes are small vesicles released by plant cells. While they share similarities with exosomes from animal cells, plant exosomes have their unique properties and functions. Some research suggests that they may have therapeutic properties, such as anti-inflammatory, antioxidant, and immunomodulatory effects.

  1. Skin Care: Plant exosomes are increasingly being explored for their use in skincare products. They are thought to help improve skin hydration, reduce inflammation, and enhance the skin’s natural protective barrier. These potential benefits make plant exosomes a valuable ingredient in cosmetics and skincare formulations.
  2. Nutraceuticals: Plant exosomes are also being investigated for their use in nutraceuticals and dietary supplements. Some believe that consuming plant-derived exosomes may support overall health and well-being.

Marine-derived exosomes and salmon-derived exosomes are two distinct types of exosomes that are gaining attention in skincare and biomedicine. Each source has its unique properties and potential applications:

  1. Marine-Derived Exosomes:
    • Source: Marine-derived exosomes are isolated from marine organisms, such as algae, plankton, and certain types of fish.
    • Skin Care: Marine-derived exosomes are increasingly used in skincare products. They are often included in formulations to help improve skin hydration, reduce the signs of aging, and enhance the skin’s natural protective barrier.
  2. Salmon-Derived Exosomes:
    • Source: Salmon-derived exosomes are isolated from salmon, a type of fish known for its rich source of nutrients, including omega-3 fatty acids.
    • Benefits: Salmon-derived exosomes are being investigated for their potential health benefits, particularly in the context of dietary supplements and nutraceuticals. Some believe that they may have anti-inflammatory and cardiovascular benefits due to their omega-3 fatty acid content.
    • Nutraceuticals: Salmon-derived exosomes are being explored as ingredients in dietary supplements. They may be consumed in the form of capsules or other oral formulations to support overall health and well-being.

It’s important to note that research on exosomes is still in its early stages, and their specific properties and potential benefits are areas of ongoing study. While there is interest in their use in skincare and health products, more scientific evidence and clinical studies are needed to establish their effectiveness and safety fully.

Despite an increasing surge of exosome use throughout the aesthetic arena, a paucity of published exosome-based literature exists and No exosome-based products are currently USA FDA approved. So exosomes are an off label use (like a few areas of anti wrinkle injections and hyaluronidase etc)

Are exosomes safe?

The short answer is yes, with the longer answer being that the scientific community isn’t so sure yet, due to limited information.

It’s worth considering some of the common potential fears of being treated with exosomes. One such concern is that your body could reject them. That’s why, when you get PRP, it has to be sourced from your own body—if a foreign cell is incompatible with your body, your immune system will attack it. Remember though: exosomes are not cells, which is why these little messengers can be extracted from various sources and used by anyone to treat a broad range of concerns.

Another concern is the health or safety of the sourced material—what if the exosomes are pulled from someone with a serious medical condition? That shouldn’t be a worry with autologous exosome treatments.

The real question with exosome safety has to do with your own health. That is why we do not offer this innovative treatment to patients who have any of the following

  • Platelet dysfunction syndrome,;
  • Critical thrombocytopenia,;
  • Hemodynamic instability;
  • Septicemia;
  • Cancer, especially hematopoietic or bone,
  • HGB <10 g / dl, Platelet count <105 / ul.

What is the SCIENTIFIC EVIDENCE?

Recent studies evaluating topical exosomes in conjunction with nonsurgical facial treatments have displayed synergistic effects.
Chernoff et al found that combining topical exosomes with facial microneedling produced greater skin quality, tone, texture, vascularity, clarity, and overall higher satisfaction among patients compared with micro-needling alone.
Duncan et al added topical exosomes after facial rejuvenation procedures such as laser resurfacing, resulting in faster recovery and fewer side effects compared with laser resurfacing alone.
A clinical trial conducted by Cho et al for hyperpigmentation treatment using adipose-derived stem cell exosomes showed a significant decrease in melanin content in the treatment group, though the decreased-melanin activity was short-lived.
Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wound repair. Studies also showed that the regenerative effect of exosomes was found to be dose dependent.
In recent years, the effects of exosomes on various skin defects have been extensively studied. The key benefits of exosomes are the high stability, non-immune rejection, and direct stimulation of target cells

Why are Exosomes controversial?

Autologous exosomes have been studied and used in various medical applications, including regenerative medicine, tissue repair and the treatment of specific conditions. They may be used to enhance healing, reduce inflammation, or promote tissue regeneration.

Safety: Autologous exosomes are considered safe from an immunological perspective, as there is no risk of immune rejection or allergic reactions when using one’s own exosomes. This makes them an attractive option for personalized regenerative therapies.

Medical Conditions: Autologous exosomes have been explored in the treatment of conditions such as osteoarthritis, wound healing, skin rejuvenation, and neurological disorders. However, the clinical evidence for their effectiveness is still evolving, and research is ongoing.

Regulatory Considerations: The regulatory status of autologous exosome therapies can vary by country and region. In some cases, they may be considered investigational and subject to regulatory oversight, while in others, they may be used under specific medical conditions or in clinical trials.

The regulatory landscape in the UK, Europe & USA may evolve over time to address emerging biotechnologies like exosomes. Regulatory agencies continue to monitor developments in the field and may update guidelines and regulations as needed.

But plenty of experimental and well-regarded aesthetic treatments are not cleared by the FDA—including PRP. Currently, the FDA has approved the use of PRP only in wound care; using it for facials or hair growth is off label. It takes hundreds of millions of dollars, in-depth studies, and often, decades to achieve FDA approval.

It’s important to note that while autologous exosomes offer the advantage of being derived from the patient’s own body, the field of autologous exosome therapies is still relatively new, and research is ongoing.

Exosomes hold promise for skin rejuvenation, the scientific research and clinical evidence supporting their effectiveness in skincare are still in the early stages. The results can vary among individuals, and not all skincare products or treatments containing exosomes may deliver the same results.

PRP (platelet rich plasma therapy) VS Exosomes

Potentially doctors have mentioned seeing more hair growth three months after a single session of exosome therapy than with PRP (which needs multiple treatments).
We often use exosomes as a replacement for or in conjunction with PRP.
This is because they have over 100 growth factors and therefore have more regenerative potential than PRP, which contains 8 to 10 growth factors.
Exosomes send signals which kickstart the cells in the treatment area. So for instance in the skin they can “awaken” keratinocytes, melanocytes and aid in promoting new collagen production.
Your body is constantly making new platelets, with a life span of 7-10 days.
PRP is a concentrated, autologous-derived product currently used as an adjunct for regenerative potential, and although reported PRP-based outcomes are via growth factors, the exosome itself stimulates the production of natural growth factors via mRNA activation
Additionally, direct comparative studies between exosomes and other modalities that may provide similar effects, such as stem cells and platelet-rich-plasma (PRP), are needed. Although the current limited evidence suggests that the cell-free characteristics of exosomes may minimize the risk of unpredictable patterns that can be associated with stem cell–based therapies, definitive evidence is currently lacking

About Dr Sabrina Shah-Desai MS, FRCS

Dr Sabrina Shah-Desai is a distinguished oculoplastic surgeon and one of London’s leading eye specialists. She has over two decades of surgical experience and is renowned for her ability to create a natural look.

Dr Sabrina has a deep anatomical knowledge of the periorbital area and an appreciation for the differences in treating both men and women. When raising the brows and eyelids in a male Upper-Lid Blepharoplasty, it is important to preserve the T-shaped brow – in order not to feminise their appearance.

Treatment Cost

Prices are a guide; your doctor will calculate total costs during consultation

£1500

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